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Further, our analyses revealed that the multi-omics signature associated with higher circulating TMAO concentrations and, therefore, elevated cardiovascular risk, shifted from obesity with increased insulin resistance toward overt T2D and IHD with only three variables (age, eGFR, and serum butyryl-carnitine) consistently being strong contributors across models built with the BMIS, T2D and IHD disease groups

Grindstaff, K., et al

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on

Medications are not a standalone solution to obesity, she said